Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | WNT3A | P56704 | 2/20 | 0.51 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.49 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1492849 | 0.87 | WNT3A (0.55) | CNR1KMT2AMEN1MAPTROCK2 | |
| SCHEMBL1492982 | 0.86 | CNR1 (0.63) | CNR1ROCK2MAPK1WNT3APORCN | |
| SCHEMBL1492868 | 0.85 | WNT3A (0.53) | CNR1ROCK2MAPK1WNT3APORCN | |
| SCHEMBL1492922 | 0.85 | CNR1 (0.60) | CNR1KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL2183208 | 0.83 | WNT3A (0.67) | KMT2AMEN1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL1492756 | 0.81 | FPR2 (0.61) | CNR1KMT2AMEN1ALDH1A1ROCK2 | |
| SCHEMBL1492960 | 0.81 | CNR1 (0.66) | CNR1KMT2AROCK2WNT3APORCN | |
| SCHEMBL1492989 | 0.81 | SMN1; SMN2 (0.62) | KMT2AMEN1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL1493027 | 0.79 | CNR1 (0.69) | CNR1MAPK1WNT3APSEN1PSEN2 | |
| SCHEMBL1492949 | 0.79 | WNT3A (0.50) | CNR1KMT2AMEN1ROCK2WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300427-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2011-03-30 | — | — | EP | claimed |
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | claimed |