Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 6/20 | 0.63 |
| ▸ | WNT3A | P56704 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | RORA | P35398 | 1/20 | 0.52 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.51 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.51 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.51 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.51 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.51 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.51 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.51 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1492849 | 0.90 | WNT3A (0.55) | CNR1WNT3AROCK2ROCK1PSEN1 | |
| SCHEMBL1492868 | 0.88 | WNT3A (0.53) | CNR1WNT3AMAPK1ROCK2ROCK1 | |
| SCHEMBL1492922 | 0.88 | CNR1 (0.60) | CNR1WNT3AMAPK1ROCK2ROCK1 | |
| SCHEMBL1493027 | 0.88 | CNR1 (0.69) | CNR1WNT3AMAPK1PSEN1PSEN2 | |
| SCHEMBL1493072 | 0.86 | CNR1 (0.63) | CNR1WNT3AMAPK1ROCK2ROCK1 | |
| SCHEMBL1492798 | 0.83 | PSEN1 (0.72) | CNR1ROCK2ROCK1PSEN1PSEN2 | |
| SCHEMBL2184203 | 0.83 | RORA (0.71) | WNT3ARORANR2E1PSEN1PSEN2 | |
| SCHEMBL1492760 | 0.83 | CNR1 (0.66) | CNR1WNT3AROCK2ROCK1PSEN1 | |
| SCHEMBL1493021 | 0.81 | CNR1 (0.60) | CNR1WNT3AROCK2ROCK1PSEN1 | |
| SCHEMBL1492967 | 0.81 | CNR1 (0.55) | CNR1WNT3AMAPK1PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300427-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2011-03-30 | — | — | EP | claimed |
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | claimed |