Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ILK | Q13418 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1493393 | 0.67 | ALDH1A1 (0.34) | GAAMAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL922676 | 0.67 | PIM1 (0.44) | MAPK1 | |
| SCHEMBL15661004 | 0.65 | GAA (0.45) | LMNAGAAMAPTKDM4EILK | |
| SCHEMBL17355073 | 0.65 | ALOX15 (0.58) | LMNAGAAMAPTKDM4EALDH1A1 | |
| SCHEMBL17355102 | 0.65 | ADORA3 (0.51) | LMNAGAAKDM4EALDH1A1NPC1 | |
| SCHEMBL2083395 | 0.65 | IDO1 (0.49) | GAAMAPTKDM4EALDH1A1MAPK1 | |
| SCHEMBL1857868 | 0.65 | NPC1 (0.54) | LMNAGAAMAPTKDM4EALDH1A1 | |
| SCHEMBL3499089 | 0.65 | ALPL (0.57) | GAAMAPTKDM4EALDH1A1HTT | |
| SCHEMBL31324688 | 0.65 | ALPL (0.57) | GAAMAPTKDM4EALDH1A1HTT | |
| SCHEMBL17980230 | 0.65 | AURKA (0.42) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104411707-B | Substituted phenylimidazopyrazoles and their use | 拜耳药业股份公司 | 2017-03-01 | — | — | CN | disclosed |
| CN-104903310-A | Bicyclic urea, thiourea, guanidine and cyanoguanidine compounds useful for the treatment of pain | ARRAY BIOPHARMA INC | 2015-09-09 | — | — | CN | disclosed |
| CN-104411707-A | Substituted phenylimidazopyrazoles and their use | Bayer Pharma AG | 2015-03-11 | — | — | CN | disclosed |
| WO-2014078325-A1 | N-(MONOCYCLIC ARYL),N'-PYRAZOLYL-UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2014-05-22 | — | — | WO | disclosed |
| WO-2012158413-A2 | PYRROLIDINYL UREA AND PYRROLIDINYL THIOUREA COMPOUNDS AS TRKA KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2012-11-22 | — | — | WO | disclosed |
| EP-2470539-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2012-07-04 | — | — | EP | disclosed |
| WO-2011025951-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2011-03-03 | — | — | WO | disclosed |