Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 13/20 | 0.74 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.74 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.74 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.74 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.74 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.74 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.74 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.74 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.74 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.74 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.74 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL675363 | 1.00 | HDAC1 (0.74) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL14946979 | 0.88 | HDAC1 (0.59) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| Ar-42 SCHEMBL31140841 | 0.85 | HDAC1 (1.00) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| Ar-42 SCHEMBL675409 | 0.85 | HDAC1 (1.00) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| Ar-42 SCHEMBL2348844 | 0.85 | HDAC1 (1.00) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL673385 | 0.84 | HDAC1 (0.69) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL7748974 | 0.84 | POLB (0.66) | POLBALDH1A1MAPTHTTMEN1 | |
| SCHEMBL17365594 | 0.84 | POLB (0.66) | POLBALDH1A1MAPTHTTMEN1 | |
| SCHEMBL673569 | 0.82 | ALDH1A1 (0.74) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL676046 | 0.82 | MAPT (0.71) | HDAC1HDAC2HDAC3HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2859890-A2 | Methods and compositions for treatment of autism | The Johns Hopkins University (US) | 2015-04-15 | — | — | EP | disclosed |
| US-20150051288-A1 | Methods and Compositions for Treatment of Autism | UNIV JOHNS HOPKINS (US) | 2015-02-19 | — | — | US | disclosed |
| US-8937050-B2 | Methods and compositions for treatment of autism | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-01-20 | — | — | US | disclosed |
| US-20130123203-A1 | METHODS AND COMPOSITIONS FOR TREATMENT OF AUTISM | KENNEDY KRIEGER INSTITUTE, INC. | 2013-05-16 | — | — | US | disclosed |
| WO-2013067040-A1 | METHODS AND COMPOSITIONS FOR TREATMENT OF AUTISM | THE JOHNS HOPKINS UNIVERSITY (US) | 2013-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150051288-A1 | Methods and Compositions for Treatment of Autism | CHAT, AHCY, SYNGR2 | HDAC1 1025/4885HDAC2 523/4885HDAC3 730/4885 |
| US-20130123203-A1 | METHODS AND COMPOSITIONS FOR TREATMENT OF AUTISM | CHAT, AHCY, SYNGR2 | HDAC1 1025/4885HDAC2 523/4885HDAC3 730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.