Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP14 | P50281 | 1/20 | 0.45 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27372181 | 0.86 | MAPT (0.41) | MMP14ADAMTS5FFAR1L3MBTL1HTT | |
| SCHEMBL189033 | 0.84 | GFER (0.46) | MMP14ADAMTS5DRD2SIGMAR1GAA | |
| SCHEMBL22471285 | 0.84 | GFER (0.46) | MMP14ADAMTS5DRD2SIGMAR1GAA | |
| SCHEMBL188824 | 0.84 | GFER (0.46) | MMP14ADAMTS5DRD2SIGMAR1GAA | |
| SCHEMBL12701198 | 0.84 | MAPK1 (0.51) | MMP14ADAMTS5DRD2DRD4L3MBTL1 | |
| SCHEMBL188654 | 0.81 | MAPK1 (0.36) | MMP14ADAMTS5DRD2DRD4HTT | |
| SCHEMBL8567524 | 0.80 | SLC6A2 (0.47) | DRD4SLC6A3SIGMAR1 | |
| SCHEMBL22471521 | 0.79 | SIRT6 (0.52) | HTTGAA | |
| SCHEMBL14921000 | 0.78 | ADAMTS5 (0.47) | MMP14ADAMTS5FFAR1HTT | |
| SCHEMBL14922270 | 0.77 | DRD2 (0.50) | MMP14ADAMTS5DRD2DRD4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013064983-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2013-05-10 | — | — | WO | disclosed |