Phorbol

Phorbol

SCHEMBL14937

CC1=C[C@H]2[C@@]3(O)[C@H](C)[C@@H](O)[C@]4(O)[C@H]([C@@H]3C=C(CO)C[C@]2(O)C1=O)C4(C)C

nearest known ligand 0.63

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKCA P17252 5/20 0.60
PRKCG P05129 5/20 0.60
PRKD3 O94806 4/20 0.60
PRKCB P05771 4/20 0.60
PRKCH P24723 4/20 0.60
PRKCI P41743 4/20 0.60
PRKCE Q02156 4/20 0.60
PRKCQ Q04759 4/20 0.60
PRKCZ Q05513 4/20 0.60
PRKCD Q05655 4/20 0.60
PRKD1 Q15139 4/20 0.60
VAV1 P15498 2/20 0.58
USP2 O75604 2/20 0.53
TP53 P04637 2/20 0.53
KDM4E B2RXH2 1/20 0.53
ALDH1A1 P00352 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
CYP3A4 P08684 1/20 0.53
CYP2C9 P11712 1/20 0.53
TSHR P16473 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phorbol SCHEMBL15976176 1.00 PRKCA (0.60) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL2329457 1.00 PRKCA (0.60) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL1733926 1.00 PRKCA (0.60) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL3403135 1.00 PRKCA (0.60) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL5667270 1.00 PRKCA (0.60) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL12950512 1.00 PRKCA (0.60) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL8190878 1.00 PRKCA (0.60) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL23880303 0.99 PRKCA (0.59) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL5310296 0.99 PRKCA (0.59) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL19435231 0.98 PRKCA (0.59) PRKCAPRKCGPRKD3PRKCBPRKCH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 44660 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3787613-B1 PKC ACTIVATION FOR USE IN TREATING EARLY ONSET SPORADIC PARKINSON'S DISEASE CEDARS SINAI MEDICAL CENTER (US) 2026-03-11 EP claimed
EP-4271199-B1 PROCESS OF PREPARING HIGH PROTEIN GUAR MEAL SHREE RAM INDIA GUMS PVT LTD (IN) 2026-02-25 EP claimed
EP-3995139-B1 COMPOSITION FOR USE IN TREATING CANCER UNIV GEORGIA STATE RES FOUND (US) 2026-02-18 EP claimed
WO-2025235403-A1 DIFFERENTIATION OF PANCREATIC ISLET CELLS VERTEX PHARMACEUTICALS INCORPORATED (US) 2025-11-13 WO claimed
EP-4358979-B1 METHOD FOR OBTAINING A PLATELET DERIVED SECRETOME AND USES THEREOF FUNDACION PARA LA INVESTIG E INNOVACION BIOSANITARIA DEL PRINCIPADO DE ASTURIAS FINBA (ES) 2025-10-08 EP claimed
EP-4244622-B1 METHOD FOR DIAGNOSING AND MONITORING SEPSIS SEROXO LTD (GB) 2025-08-13 EP claimed
EP-4168585-B1 METHOD OF DETECTING INFECTION WITH PATHOGENS CAUSING TUBERCULOSIS MIKROGEN GMBH (DE) 2025-07-30 EP claimed
EP-4573367-A2 POINT-OF-CARE ON-CHIP IGRA DEVICE AND METHOD FOR MEASURING SPECIFIC T CELL ACTIVATION The Administrators of The Tulane Educational Fund (US) 2025-06-25 EP claimed
WO-2025122943-A1 COMPOSITIONS AND METHODS FOR ENHANCED PAYLOAD REGULATION USING NUCLEAR FACTOR OF ACTIVATED T CELLS (NFAT) RESPONSE ELEMENTS OBSIDIAN THERAPEUTICS, INC. (US) 2025-06-12 WO claimed
US-12311024-B2 Cancer cell-targeted drug delivery carrier and composition for promoting photo-thermal treatment effects, both of which contain M1 macrophages as active ingredient KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (KR) 2025-05-27 US claimed
EP-0153357-A1 PROCESS FOR PRODUCING HUMAN INTERLEUKINE 1 AND RELATED DRUGS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 1985-09-04 EP claimed
US-4518526-A Purification and activity assurance of precipitated heterologous proteins GENENTECH, INC. (US) 1985-05-21 US claimed
EP-0135797-A2 Process for preparing lymphotoxin and lymphotoxin-mRNA BOEHRINGER INGELHEIM INTERNATIONAL GmbH (DE) 1985-04-03 EP claimed
WO-1985000830-A1 PROCESS FOR PRODUCING HUMAN INTERLEUKINE 1 AND RELATED DRUGS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE M (FR) 1985-02-28 WO claimed
EP-0117060-A2 Methods of screening and amplification in eukaryotic host cells, and nucleotide sequences and expression vectors for use therein GENENTECH, INC. (US) 1984-08-29 EP claimed
EP-0117059-A2 Methods for producing human tPA and expression vectors therefor GENENTECH, INC. (US) 1984-08-29 EP claimed
US-4468328-A Purification of 12-O-tetradecanoylphorbol-13-acetate, phorbol, and 4α- THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILL. (US) 1984-08-28 US claimed
EP-0108919-A2 Process for producing T cell-activating factor Okai, Yasuji (JP) 1984-05-23 EP claimed
US-4376821-A Production of human IFN-gamma (immune) interferon MELOY LABORATORIES, INC. (US) 1983-03-15 US claimed
US-4376822-A LEUKOCYTES MODULATED WITH MEZEREIN OR 12,13 PHORBOL DIBUTYRATE MELOY LABORATORIES, INC. (US) 1983-03-15 US claimed