Phorbol

Phorbol

SCHEMBL2329457

CC1=C[C@H]2[C@]3(O)[C@H](C)[C@@H](O)[C@@]4(O)[C@H]([C@@H]3C=C(CO)C[C@@]2(O)C1=O)C4(C)C

nearest known ligand 0.63

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKCA P17252 5/20 0.60
PRKCG P05129 5/20 0.60
PRKD3 O94806 4/20 0.60
PRKCB P05771 4/20 0.60
PRKCH P24723 4/20 0.60
PRKCI P41743 4/20 0.60
PRKCE Q02156 4/20 0.60
PRKCQ Q04759 4/20 0.60
PRKCZ Q05513 4/20 0.60
PRKCD Q05655 4/20 0.60
PRKD1 Q15139 4/20 0.60
VAV1 P15498 2/20 0.58
USP2 O75604 2/20 0.53
TP53 P04637 2/20 0.53
KDM4E B2RXH2 1/20 0.53
ALDH1A1 P00352 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
CYP3A4 P08684 1/20 0.53
CYP2C9 P11712 1/20 0.53
TSHR P16473 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phorbol SCHEMBL15976176 1.00 PRKCA (0.60) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL1733926 1.00 PRKCA (0.60) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL3403135 1.00 PRKCA (0.60) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL5667270 1.00 PRKCA (0.60) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL12950512 1.00 PRKCA (0.60) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL14937 1.00 PRKCA (0.60) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL8190878 1.00 PRKCA (0.60) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL23880303 0.99 PRKCA (0.59) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL5310296 0.99 PRKCA (0.59) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL19435231 0.98 PRKCA (0.59) PRKCAPRKCGPRKD3PRKCBPRKCH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025072196-A1 METHODS FOR CULTURING AND ASSAYING B CELL LYMPHOCYTES BRUKER CELLULAR ANALYSIS, INC. (US) 2025-04-03 WO claimed
US-6080784-A Protein kinase C modulators N PROCYON PHARMACEUTICALS, INC. (US) 2000-06-27 US claimed
US-5955501-A DERIVED FROM PHORBOIDS OF THE DITERPENE- AND BENZOLACTAM-CLASSES. PROCYON PHARMACEUTICALS, INC. (US) 1999-09-21 US claimed
EP-0457295-B1 Use of a modulator of protein phosphorylation in the treatment of amyloidosis associated with Alzheimer's disease UNIV ROCKEFELLER (US) 1997-04-09 EP claimed
WO-2025072196-A1 METHODS FOR CULTURING AND ASSAYING B CELL LYMPHOCYTES BRUKER CELLULAR ANALYSIS, INC. (US) 2025-04-03 WO disclosed
CN-111826431-B Biomarkers and targets for diagnosis and treatment of cardiovascular diseases and application thereof 中国人民解放军军事科学院军事医学研究院 2022-06-17 CN disclosed
CN-108712913-A Tri-part modulators of endosomal G protein-coupled receptors 武田药品工业株式会社 2018-10-26 CN disclosed
CN-103087991-B Reprogram T cell and the method for hematopoietic cell 富士胶片细胞动力公司 2018-06-12 CN disclosed
CN-108025024-A Modified monocytes/macrophages expressing chimeric antigen receptors and uses thereof 宾夕法尼亚大学董事会 2018-05-11 CN disclosed
CN-107338217-A The differentiation of human embryo stem cell 詹森生物科技公司 2017-11-10 CN disclosed
CN-102884176-B Differentiation of human embryonic stem cells 詹森生物科技公司 2017-09-05 CN disclosed
CN-105001196-B Stem cell cultures 斯克里普斯研究所 2017-05-10 CN disclosed
CN-101460455-A 9,10-secopregnane derivative and pharmaceutical NIPPON SHINYAKU CO LTD (JP) 2009-06-17 CN disclosed
US-20080305502-A1 Method of Screening Baff Suppressor or Inhibitor KOWA COMPANY, LTD. (JP) 2008-12-11 US disclosed
WO-2007121429-A2 METHODS AND COMPOSITIONS FOR THE SYNERGISTIC ACTIVATION OF LATENT HIV J. DAVID GLADSTONE INSTITUTES (US) 2007-10-25 WO disclosed
US-7261901-B2 Vaccine and compositions for the prevention and treatment of neisserial infections UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 2007-08-28 US disclosed
CN-1662646-A Method for culturing hvc virus in vitro BIOMERIEUX SA (FR) 2005-08-31 CN disclosed
US-20040253222-A1 Vaccine and compositions for the prevention and treatment of neisserial infections NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2004-12-16 US disclosed
US-4757019-A Culturing mixture of epidermal cells containing keratinocytes, melanocytes, langerhans cells, and fibroblast SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1988-07-12 US disclosed
US-4716179-A Use of non-irritating or slightly irritating and/or promoting diterpene alcohol and of derivatives thereof as antineoplastic preparations STIFTUNG DEUTCHES KREBSFORSCHUNGSZENTRUM (DE) 1987-12-29 US disclosed