Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14782262 | 0.90 | ALDH1A1 (0.42) | ALDH1A1CYP2D6L3MBTL1NPC1RAB9A | |
| SCHEMBL25083003 | 0.88 | ALDH1A1 (0.54) | ALDH1A1CYP2D6L3MBTL1NPC1RAB9A | |
| SCHEMBL14782199 | 0.86 | SMN1; SMN2 (0.41) | ALDH1A1CYP2D6L3MBTL1NPC1RAB9A | |
| SCHEMBL6814613 | 0.77 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1SMN1; SMN2CYP3A4TDP1 | |
| SCHEMBL14782151 | 0.77 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1SMN1; SMN2CYP3A4TDP1 | |
| SCHEMBL31236322 | 0.74 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1CYP3A4TDP1LMNA | |
| SCHEMBL27982502 | 0.73 | RAB9A (0.50) | ALDH1A1CYP2D6L3MBTL1NPC1RAB9A | |
| SCHEMBL14782260 | 0.73 | ALDH1A1 (0.53) | ALDH1A1CYP2D6L3MBTL1CYP3A4TDP1 | |
| SCHEMBL15934397 | 0.73 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1CYP3A4TDP1LMNA | |
| SCHEMBL7141939 | 0.73 | HTT (0.49) | ALDH1A1L3MBTL1CYP3A4CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3670523-B1 | 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND THEIR USE IN METHODS FOR NUCLEIC ACID SEQUENCING | AGILENT TECHNOLOGIES INC (US) | 2021-08-11 | — | — | EP | disclosed |
| US-11001886-B2 | 3′-OH unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing | AGILENT TECHNOLOGIES, INC. (US) | 2021-05-11 | — | — | US | disclosed |
| EP-2755984-B1 | 5-METHOXY. 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING | AGILENT TECHNOLOGIES INC (US) | 2020-02-12 | — | — | EP | disclosed |
| US-20190127790-A1 | 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING | AGILENT TECHNOLOGIES, INC. | 2019-05-02 | — | — | US | disclosed |
| US-10041115-B2 | 3′-OH unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing | LASERGEN, INC. (US) | 2018-08-07 | — | — | US | disclosed |
| US-20170327886-A1 | 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING | LASERGEN, INC. (US) | 2017-11-16 | — | — | US | disclosed |
| US-9689035-B2 | 3′-OH unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing | LASERGEN, INC. (US) | 2017-06-27 | — | — | US | disclosed |
| US-20160369336-A1 | 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING | LASERGEN, INC. (US) | 2016-12-22 | — | — | US | disclosed |
| US-20150176074-A1 | 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING | LASERGEN, INC. (US) | 2015-06-25 | — | — | US | disclosed |
| US-8889860-B2 | 3′-OH unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing | LASERGEN, INC. (US) | 2014-11-18 | — | — | US | disclosed |
| US-20130122489-A1 | 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING | AGILENT TECHNOLOGIES, INC. | 2013-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150176074-A1 | 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING | RNGTT, NT5C3B, NSUN2 | ALDH1A1 2244/4885CYP2D6 782/4885L3MBTL1 196/4885 |
| US-20190127790-A1 | 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING | RNGTT, NT5C3B, NSUN2 | ALDH1A1 2244/4885CYP2D6 782/4885L3MBTL1 196/4885 |
| US-10041115-B2 | 3′-OH unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing | RNGTT, NT5C3B, NSUN2 | ALDH1A1 2163/4885CYP2D6 759/4885L3MBTL1 205/4885 |
| US-11001886-B2 | 3′-OH unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing | RNGTT, NT5C3B, NSUN2 | ALDH1A1 2163/4885CYP2D6 759/4885L3MBTL1 205/4885 |
| US-20170327886-A1 | 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING | RNGTT, NT5C3B, NSUN2 | ALDH1A1 2244/4885CYP2D6 782/4885L3MBTL1 196/4885 |
| US-20160369336-A1 | 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING | RNGTT, NT5C3B, NSUN2 | ALDH1A1 2244/4885CYP2D6 782/4885L3MBTL1 196/4885 |
| US-20130122489-A1 | 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING | RNGTT, NT5C3B, NSUN2 | ALDH1A1 2244/4885CYP2D6 782/4885L3MBTL1 196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.