Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MDM4 | O15151 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TYR | P14679 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14939457 | 0.83 | NPSR1 (0.49) | ALDH1A1HTTHDAC4MAPTSMN1; SMN2 | |
| SCHEMBL14938940 | 0.79 | NPSR1 (0.49) | ALDH1A1HTTMAPTSMN1; SMN2TDP1 | |
| SCHEMBL14939783 | 0.79 | CASP6 (0.40) | KIF11ALDH1A1HTTMAPTNPSR1 | |
| SCHEMBL14938934 | 0.79 | LMNA (0.38) | HTTNPSR1LMNAL3MBTL1UTS2R | |
| SCHEMBL14940276 | 0.78 | PPIB (0.43) | HPGDALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL14939565 | 0.78 | NPSR1 (0.44) | HSD17B10KIF11ALDH1A1HTTKDM4E | |
| SCHEMBL14939739 | 0.76 | NPSR1 (0.40) | ALDH1A1HTTMAPTSMN1; SMN2TDP1 | |
| SCHEMBL14939574 | 0.74 | MAPT (0.41) | HPGDHSD17B10ALDH1A1HTTKDM4E | |
| SCHEMBL14939279 | 0.72 | NPSR1 (0.43) | HSD17B10ALDH1A1HTTKDM4EMAPT | |
| SCHEMBL14939208 | 0.71 | LMNA (0.42) | ALDH1A1HDAC4KDM4EMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |