Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | AGXT | P21549 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | TDP2 | O95551 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14939345 | 0.87 | MAPT (0.46) | PDK2AGXTMAPTALDH1A1MEN1 | |
| SCHEMBL14939995 | 0.86 | MAPT (0.45) | PDK2AGXTMAPTALDH1A1MEN1 | |
| SCHEMBL14939704 | 0.84 | ADRA2C (0.48) | LMNAPDK2AGXTMAPTKMT2A | |
| SCHEMBL14938965 | 0.74 | NPSR1 (0.67) | LMNAAGXTMAPTALDH1A1KIF11 | |
| SCHEMBL27329825 | 0.72 | LMNA (0.71) | LMNAKMOAGXTMAPTALDH1A1 | |
| SCHEMBL4699438 | 0.71 | AGXT (0.54) | LMNAKMOAGXTMAPTALDH1A1 | |
| SCHEMBL14940158 | 0.70 | NPSR1 (0.53) | LMNAMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL14939632 | 0.70 | CA1 (0.43) | MAPTALDH1A1SMN1; SMN2RAB9ATDP1 | |
| SCHEMBL14939727 | 0.69 | CYP3A4 (0.52) | LMNAKMOPSMD14AGXTMAPT | |
| SCHEMBL14973406 | 0.69 | PSMD14 (0.68) | LMNAPSMD14PDK2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |