SCHEMBL14939704

SCHEMBL14939704

CN1CCN(c2cccc(C3(Br)C(=O)c4ccccc4C3=O)c2)CC1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA2C P18825 1/20 0.48
MAPT P10636 3/20 0.46
PDK2 Q15119 1/20 0.44
AGXT P21549 1/20 0.44
HTR3A P46098 1/20 0.43
HTR1A P08908 5/20 0.43
HTR2C P28335 2/20 0.43
HTR2A P28223 1/20 0.43
HTR7 P34969 1/20 0.43
DRD3 P35462 1/20 0.43
HTR6 P50406 1/20 0.43
PRKCB P05771 1/20 0.42
PRKCA P17252 1/20 0.42
PRKCH P24723 1/20 0.42
PRKCE Q02156 1/20 0.42
PRKCQ Q04759 1/20 0.42
PRKCD Q05655 1/20 0.42
EGFR P00533 1/20 0.42
LMNA P02545 1/20 0.42
MAPK1 P28482 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14939345 0.87 MAPT (0.46) MAPTPDK2AGXTEGFRMAPK1
SCHEMBL14939995 0.86 MAPT (0.45) MAPTPDK2AGXTEGFRMAPK1
SCHEMBL14939375 0.84 LMNA (0.46) MAPTPDK2AGXTLMNAKMT2A
SCHEMBL14940181 0.74 NPSR1 (0.67) MAPTAGXTHTR1AHTR7DRD3
SCHEMBL14940158 0.73 NPSR1 (0.53) MAPTLMNAMAPK1KMT2ATDP2
SCHEMBL14939119 0.72 MAPT (0.51) MAPTHTR1AHTR7DRD3LMNA
SCHEMBL14940024 0.71 MAPT (0.50) MAPTHTR1AHTR7DRD3LMNA
SCHEMBL14939005 0.71 KMT2A (0.49) MAPTMAPK1KMT2A
SCHEMBL14939632 0.70 CA1 (0.43) MAPTMAPK1
SCHEMBL7924167 0.69 KCNH2 (0.67) ADRA2CMAPTAGXTHTR3AHTR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013068785-A1 INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS ACTELION PHARMACEUTICALS LTD (CH) 2013-05-16 WO disclosed