Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | GALK1 | P51570 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 5/20 | 0.38 |
| ▸ | CA2 | P00918 | 5/20 | 0.38 |
| ▸ | CA7 | P43166 | 5/20 | 0.38 |
| ▸ | CA9 | Q16790 | 5/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | STK10 | O94804 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14939980 | 0.80 | CA1 (0.59) | MAPTKDM4EBLMCA1CA2 | |
| SCHEMBL14939484 | 0.80 | CA1 (0.57) | MAPTCA1CA2CA7CA9 | |
| SCHEMBL14939600 | 0.80 | CA1 (0.57) | MAPTCA1CA2CA7CA9 | |
| SCHEMBL14939057 | 0.80 | ALDH1A1 (0.52) | NSD2MAPTKDM4EAPAF1TDP2 | |
| SCHEMBL10834251 | 0.78 | SLC6A3 (0.42) | MAPTKDM4ECA1CA2CA7 | |
| SCHEMBL14939084 | 0.76 | CA1 (0.60) | MAPTKDM4EAPAF1CA1CA2 | |
| SCHEMBL11592235 | 0.74 | S100A4 (0.44) | NSD2MAPTKDM4EAPAF1TDP2 | |
| SCHEMBL11144606 | 0.73 | CA1 (0.44) | NSD2MAPTKDM4EAPAF1TDP2 | |
| SCHEMBL14940123 | 0.73 | ALDH1A1 (0.47) | MAPTKDM4ECA1CA2CA7 | |
| SCHEMBL14939451 | 0.72 | MAPT (0.42) | NSD2MAPTKDM4EAPAF1TDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |