Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | AGXT | P21549 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20831616 | 0.91 | KCNH2 (0.38) | KCNH2HTR2ASLC6A4PSEN1PSEN2 | |
| SCHEMBL3667517 | 0.86 | IDO1 (0.40) | KCNH2HTR2ASLC6A4PSEN1PSEN2 | |
| SCHEMBL28056457 | 0.86 | IDO1 (0.40) | KCNH2HTR2ASLC6A4PSEN1PSEN2 | |
| SCHEMBL5824286 | 0.80 | IDO1 (0.36) | KCNH2HTR2ASLC6A4PSEN1PSEN2 | |
| SCHEMBL16587909 | 0.80 | RIPK1 (0.37) | KCNH2HTR2ASLC6A4PSEN1PSEN2 | |
| SCHEMBL27655715 | 0.79 | F2RL1 (0.39) | KCNH2MAPTSMN1; SMN2IDO1AGXT | |
| SCHEMBL13548272 | 0.78 | MAPT (0.39) | KCNH2HTR2ASLC6A4PSEN1PSEN2 | |
| SCHEMBL12525261 | 0.78 | MPO (0.43) | KCNH2HTR2ASLC6A4RIPK1MAPT | |
| SCHEMBL19859248 | 0.78 | IDO1 (0.40) | KCNH2HTR2ASLC6A4MAPTSMN1; SMN2 | |
| SCHEMBL28538413 | 0.77 | IDO1 (0.38) | KCNH2HTR2ASLC6A4RIPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |