Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | AGXT | P21549 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8418213 | 0.91 | RIPK1 (0.37) | RIPK1MAPTPKMSMN1; SMN2IDO1 | |
| SCHEMBL3667517 | 0.88 | IDO1 (0.40) | RIPK1MAPTPKMSMN1; SMN2IDO1 | |
| SCHEMBL14939746 | 0.80 | KCNH2 (0.38) | RIPK1MAPTPKMSMN1; SMN2IDO1 | |
| SCHEMBL13548272 | 0.80 | MAPT (0.39) | RIPK1MAPTPKMSMN1; SMN2IDO1 | |
| SCHEMBL12525261 | 0.80 | MPO (0.43) | RIPK1MAPTPKMSMN1; SMN2IDO1 | |
| SCHEMBL12464215 | 0.79 | MAPT (0.39) | MAPTSMN1; SMN2KDM4EHTTHSD17B10 | |
| SCHEMBL28538413 | 0.78 | IDO1 (0.38) | RIPK1MAPTPKMSMN1; SMN2IDO1 | |
| SCHEMBL31021755 | 0.77 | IDO1 (0.36) | SMN1; SMN2IDO1AGXTKDM4EPSEN1 | |
| SCHEMBL12926917 | 0.77 | MPO (0.44) | SMN1; SMN2IDO1AGXTHTR2AKDM4E | |
| SCHEMBL15256477 | 0.77 | DHFR (0.38) | MAPTSMN1; SMN2SLC6A4KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016174551-A1 | ANTI-ESTROGENIC COMPOUNDS | PFIZER INC. (US) | 2016-11-03 | — | — | WO | disclosed |
| US-8987473-B2 | Ring-fused compound | SATO PHARMACEUTICAL CO., LTD. (JP) | 2015-03-24 | — | — | US | disclosed |