SCHEMBL5824286

SCHEMBL5824286

FCc1ccc(F)cc1CCl

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 4/20 0.36
AGXT P21549 2/20 0.36
GPR84 Q9NQS5 3/20 0.34
PSEN1 P49768 1/20 0.33
PSEN2 P49810 1/20 0.33
APH1B Q8WW43 1/20 0.33
NCSTN Q92542 1/20 0.33
APH1A Q96BI3 1/20 0.33
PSENEN Q9NZ42 1/20 0.33
KDM4E B2RXH2 2/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
MPO P05164 2/20 0.31
GRM5 P41594 1/20 0.31
HTR2A P28223 1/20 0.30
SLC6A4 P31645 1/20 0.30
KCNH2 Q12809 1/20 0.30
CA3 P07451 1/20 0.30
CA6 P23280 1/20 0.30
CA5A P35218 1/20 0.30
CA9 Q16790 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28056457 0.88 IDO1 (0.40) IDO1AGXTGPR84PSEN1PSEN2
SCHEMBL14939746 0.80 KCNH2 (0.38) IDO1AGXTPSEN1PSEN2APH1B
SCHEMBL8418213 0.77 RIPK1 (0.37) IDO1AGXTGPR84PSEN1PSEN2
SCHEMBL12927144 0.77 MPO (0.44) IDO1AGXTGPR84MPOHTR2A
SCHEMBL2708686 0.76 PSEN1 (0.47) IDO1AGXTPSEN1PSEN2APH1B
SCHEMBL1503215 0.76 IDO1 (0.54) IDO1AGXTKDM4ESMN1; SMN2HTR2A
SCHEMBL20831616 0.76 KCNH2 (0.38) IDO1AGXTPSEN1PSEN2APH1B
SCHEMBL19859248 0.75 IDO1 (0.40) IDO1AGXTKDM4ESMN1; SMN2GRM5
SCHEMBL8290760 0.74 ALDH1A1 (0.42) KDM4ESMN1; SMN2ALDH1A1CYP1A2
SCHEMBL531667 0.74 ALDH1A1 (0.43) KDM4ESMN1; SMN2ALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2006160635-A METHOD FOR PRODUCING 2-TRIFLUOROMETHYL-5-FLUOROBENZALDEHYDE AND ITS DERIVATIVE CENTRAL GLASS CO LTD 2006-06-22 JP disclosed