Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 12/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 10/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14940355 | 0.90 | HCRTR2 (0.45) | NPSR1NPC1RAB9AHCRTR2HCRTR1 | |
| SCHEMBL14939271 | 0.88 | MEN1 (0.44) | NPSR1KDM4EALDH1A1HTR1A | |
| SCHEMBL14940076 | 0.86 | NPSR1 (0.46) | NPSR1NPC1RAB9APOLBFAAH | |
| SCHEMBL14939887 | 0.85 | NPSR1 (0.64) | NPSR1NPC1RAB9AHCRTR2HCRTR1 | |
| SCHEMBL14939899 | 0.83 | NPSR1 (0.48) | NPSR1ADAM17 | |
| SCHEMBL14939260 | 0.82 | NPSR1 (0.49) | NPSR1KDM4EALDH1A1POLB | |
| SCHEMBL14938910 | 0.81 | NPSR1 (0.46) | NPSR1KDM4EALDH1A1 | |
| SCHEMBL14939130 | 0.80 | NPSR1 (0.47) | NPSR1 | |
| SCHEMBL14939940 | 0.80 | NPSR1 (0.47) | NPSR1NPC1ADAM17 | |
| SCHEMBL14939657 | 0.79 | NPSR1 (0.46) | NPSR1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | claimed |
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |