Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14939086 | 0.89 | SIGMAR1 (0.50) | NPSR1DRD2DRD4DRD3L3MBTL1 | |
| SCHEMBL14939274 | 0.88 | NPSR1 (0.44) | NPSR1DRD2DRD4DRD3MAPT | |
| SCHEMBL14938968 | 0.88 | ALDH1A1 (0.45) | NPSR1SMN1; SMN2MAPTSIGMAR1ALDH1A1 | |
| SCHEMBL14939313 | 0.87 | KMT2A (0.43) | NPSR1DRD2DRD4DRD3PKM | |
| SCHEMBL14939998 | 0.85 | MEN1 (0.45) | NPSR1DRD2L3MBTL1ALDH1A1GAA | |
| SCHEMBL14940461 | 0.84 | NPSR1 (0.62) | NPSR1DRD2MMP2MMP9L3MBTL1 | |
| SCHEMBL14939259 | 0.83 | NPSR1 (0.65) | NPSR1DRD2MMP2MMP9L3MBTL1 | |
| SCHEMBL14939426 | 0.82 | NPSR1 (0.67) | NPSR1DRD2MMP2MMP9L3MBTL1 | |
| SCHEMBL14939341 | 0.81 | NPSR1 (0.65) | NPSR1DRD2MMP2MMP9L3MBTL1 | |
| SCHEMBL14939412 | 0.79 | NPSR1 (0.70) | NPSR1DRD2MMP2MMP9OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | claimed |
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |