SCHEMBL14940465

SCHEMBL14940465

COc1cccc(CN2CCN(C3(c4cccc(F)c4)Cc4ccccc4C3=O)CC2)c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 2/20 0.50
ALDH1A1 P00352 7/20 0.48
ALDH3A1 P30838 1/20 0.48
KDM4E B2RXH2 5/20 0.46
MEN1 O00255 3/20 0.46
KMT2A Q03164 3/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
CHRM2 P08172 1/20 0.44
CHRM3 P20309 1/20 0.44
DRD2 P14416 1/20 0.44
HTR2A P28223 1/20 0.44
HTR2C P28335 1/20 0.44
HTR2B P41595 1/20 0.44
TACR1 P25103 2/20 0.44
HTT P42858 1/20 0.43
FAAH O00519 1/20 0.43
ACHE P22303 1/20 0.42
POLB P06746 1/20 0.42
GAA P10253 1/20 0.42
LMNA P02545 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14939907 0.93 SIGMAR1 (0.55) SIGMAR1ALDH1A1ALDH3A1KDM4EMEN1
SCHEMBL14939908 0.90 SIGMAR1 (0.51) SIGMAR1ALDH1A1ALDH3A1KDM4EMEN1
SCHEMBL14940301 0.89 SIGMAR1 (0.55) SIGMAR1ALDH1A1ALDH3A1CHRM2CHRM3
SCHEMBL14939852 0.88 NPSR1 (0.54) SIGMAR1ALDH1A1ALDH3A1SMN1; SMN2CHRM2
SCHEMBL14940346 0.85 SIGMAR1 (0.44) SIGMAR1ALDH1A1DRD2HTR2AHTR2C
SCHEMBL14939591 0.85 SIGMAR1 (0.50) SIGMAR1ALDH1A1ALDH3A1KDM4EMEN1
SCHEMBL14940002 0.85 NPSR1 (0.50) SIGMAR1ALDH1A1ALDH3A1SMN1; SMN2CHRM2
SCHEMBL14939844 0.85 NPSR1 (0.45) SIGMAR1ALDH1A1ALDH3A1KDM4EMEN1
SCHEMBL14939342 0.84 CYP2D6 (0.48) ALDH1A1MEN1KMT2ACHRM3DRD2
SCHEMBL14940059 0.82 NPSR1 (0.49) SIGMAR1ALDH1A1ALDH3A1CHRM2CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013068785-A1 INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS ACTELION PHARMACEUTICALS LTD (CH) 2013-05-16 WO claimed
WO-2013068785-A1 INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS ACTELION PHARMACEUTICALS LTD (CH) 2013-05-16 WO disclosed