Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14940351 | 0.81 | KMT2A (0.37) | MAPTCRHBPCRHR2SMN1; SMN2GFER | |
| SCHEMBL26288710 | 0.79 | KMT2A (0.51) | MAPTS1PR1CHRM4LMNAHIF1A | |
| SCHEMBL26288600 | 0.79 | KMT2A (0.51) | MAPTS1PR1CHRM4LMNAHIF1A | |
| SCHEMBL2477886 | 0.77 | ALDH1A1 (0.47) | MAPTSMN1; SMN2TP53LMNAKMT2A | |
| SCHEMBL14940517 | 0.75 | ALDH1A1 (0.46) | MAPTSMN1; SMN2TP53LMNAKMT2A | |
| SCHEMBL27828825 | 0.74 | KDM4E (0.46) | MAPTCRHBPCRHR2SMN1; SMN2GFER | |
| SCHEMBL2479088 | 0.72 | KDM4E (0.39) | MAPTSMN1; SMN2LMNAKMT2ACYP1A2 | |
| SCHEMBL1031411 | 0.72 | MAOA (0.47) | MAPTSMN1; SMN2GFERTP53CHRM4 | |
| SCHEMBL1030749 | 0.72 | MAOA (0.47) | MAPTSMN1; SMN2GFERTP53CHRM4 | |
| SCHEMBL1028721 | 0.72 | MAOA (0.47) | MAPTSMN1; SMN2GFERTP53CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068592-A1 | INHIBITORS OF CYSTATHIONINE BETA SYNTHASE TO REDUCE THE NEUROTOXIC OVERPRODUCTION OF ENDOGENOUS HYDROGEN SULFIDE | FONDATION JEROME LEJEUNE (FR) | 2013-05-16 | — | — | WO | disclosed |