Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 9/20 | 0.51 |
| ▸ | FBP1 | P09467 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15366422 | 1.00 | NOS1 (0.51) | NOS1FBP1ELANE | |
| SCHEMBL8820639 | 0.86 | NOS1 (0.53) | NOS1FBP1ELANE | |
| SCHEMBL14936428 | 0.79 | NOS1 (0.49) | NOS1ELANE | |
| SCHEMBL11686773 | 0.78 | NOS1 (0.61) | NOS1FBP1 | |
| Hydrochloric Acid SCHEMBL2378442 | 0.77 | NOS1 (0.59) | NOS1FBP1 | |
| SCHEMBL7499635 | 0.77 | NOS1 (0.58) | NOS1 | |
| Carbamic Acid SCHEMBL612588 | 0.76 | NOS1 (0.41) | NOS1ELANE | |
| SCHEMBL5391387 | 0.75 | — | — | |
| SCHEMBL19545548 | 0.75 | — | — | |
| SCHEMBL1421922 | 0.75 | NOS1 (0.45) | NOS1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873673-B2 | 2-thiopyrimidinones | PFIZER INC. (US) | 2018-01-23 | — | — | US | disclosed |
| US-20160304469-A1 | 2-Thiopyrimidinones | PFIZER INC. (US) | 2016-10-20 | — | — | US | disclosed |
| US-9399626-B2 | 2-thiopyrimidinones | PFIZER INC. (US) | 2016-07-26 | — | — | US | disclosed |
| US-20140288049-A1 | 2-Thiopyrimidinones | PFIZER (US) | 2014-09-25 | — | — | US | disclosed |
| US-8841314-B2 | 2-Thiopyrimidinones | PFIZER INC. (US) | 2014-09-23 | — | — | US | disclosed |
| EP-2776405-A1 | 2-THIOPYRIMIDINONES | Pfizer Inc (US) | 2014-09-17 | — | — | EP | disclosed |
| US-20130296351-A1 | 2-Thiopyrimidinones | PFIZER INC. | 2013-11-07 | — | — | US | disclosed |
| WO-2013068875-A1 | 2-THIOPYRIMIDINONES | PFIZER INC. (US) | 2013-05-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160304469-A1 | 2-Thiopyrimidinones | MPO, SERPINB1, TNNI3 | NOS1 397/4885FBP1 1006/4885ELANE 67/4885 |
| US-20140288049-A1 | 2-Thiopyrimidinones | MPO, SERPINB1, TNNI3 | NOS1 397/4885FBP1 1006/4885ELANE 67/4885 |
| US-20130296351-A1 | 2-Thiopyrimidinones | MPO, SERPINB1, TNNI3 | NOS1 397/4885FBP1 1006/4885ELANE 67/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.