Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 7/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | MYC | P01106 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22232304 | 0.81 | ALDH1A1 (0.44) | ALDH1A1RAB9ASMN1; SMN2NPC1GPR35 | |
| SCHEMBL29177299 | 0.81 | GPR35 (0.43) | ALDH1A1RAB9ASMN1; SMN2GPR35KMT2A | |
| SCHEMBL30699721 | 0.80 | MAPK1 (0.48) | ALDH1A1RAB9ASMN1; SMN2NPC1GPR35 | |
| SCHEMBL1494511 | 0.80 | RAB9A (0.39) | ALDH1A1RAB9ASMN1; SMN2NPC1GPR35 | |
| SCHEMBL6524156 | 0.79 | LCK (0.40) | ALDH1A1RAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL15408633 | 0.76 | GPR35 (0.44) | GPR35KMT2AMEN1 | |
| SCHEMBL22831837 | 0.75 | TSHR (0.44) | ALDH1A1RAB9ASMN1; SMN2KMT2ALMNA | |
| SCHEMBL3226790 | 0.75 | CA1 (0.32) | ALDH1A1 | |
| SCHEMBL25314279 | 0.74 | MAPT (0.39) | ALDH1A1RAB9ASMN1; SMN2NPC1GPR35 | |
| SCHEMBL31038672 | 0.74 | MAPT (0.39) | ALDH1A1RAB9ASMN1; SMN2NPC1GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2470528-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | Novartis AG (CH) | 2012-07-04 | — | — | EP | disclosed |
| WO-2011023773-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-03-03 | — | — | WO | disclosed |