Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP1 | O94782 | 5/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 11/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 10/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20343814 | 0.80 | USP1 (0.37) | USP1ADORA1TLR7 | |
| SCHEMBL14944713 | 0.75 | ADORA1 (0.35) | USP1HCRTR1HCRTR2ADORA1TLR7 | |
| SCHEMBL14944715 | 0.73 | TLR7 (0.41) | USP1HCRTR1HCRTR2ADORA1TLR7 | |
| SCHEMBL16206183 | 0.72 | TLR7 (0.42) | USP1ADORA1TLR7 | |
| SCHEMBL14944647 | 0.59 | TLR7 (0.41) | TLR7 | |
| SCHEMBL20343751 | 0.58 | PNP (0.38) | TLR7 | |
| SCHEMBL20343763 | 0.57 | TLR7 (0.42) | ADORA1TLR7 | |
| SCHEMBL20134287 | 0.57 | GRIN1 (0.57) | GRIN1GRIN2B | |
| SCHEMBL2690888 | 0.57 | RAB9A (0.41) | HSP90AA1HSP90AB1TLR7 | |
| SCHEMBL17434630 | 0.57 | RAB9A (0.41) | HSP90AA1HSP90AB1TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2776439-B1 | PURINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UC (IE) | 2018-07-04 | — | — | EP | disclosed |
| WO-2013068438-A1 | PURINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN R&D IRELAND (IE) | 2013-05-16 | — | — | WO | disclosed |