SCHEMBL14946314

SCHEMBL14946314

CC(=O)Nc1ccn([C@@H]2O[C@@H]3CO[Si](C(C)C)(C(C)C)O[Si](C(C)C)(C(C)C)O[C@@H]3C2C)c(=O)n1

nearest known ligand 0.39

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 1/20 0.32
▸ ABL1 P00519 1/20 0.32
▸ RIN1 Q13671 1/20 0.32
▸ POLB P06746 1/20 0.31
▸ ROCK2 O75116 1/20 0.31
▸ NT5E P21589 1/20 0.30
▸ P2RY6 Q15077 1/20 0.30
▸ P2RY14 Q15391 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20215740 0.92 P2RY6 (0.34) MAPTABL1RIN1POLBROCK2
SCHEMBL14946367 0.92 P2RY6 (0.34) MAPTABL1RIN1POLBROCK2
SCHEMBL10459464 0.92 P2RY6 (0.34) MAPTABL1RIN1POLBROCK2
SCHEMBL1937265 0.92 P2RY6 (0.34) MAPTABL1RIN1POLBROCK2
SCHEMBL19981007 0.92 P2RY6 (0.34) MAPTABL1RIN1POLBROCK2
SCHEMBL20459987 0.92 P2RY6 (0.34) MAPTABL1RIN1POLBROCK2
SCHEMBL30274755 0.88 ACHE (0.33) MAPTABL1RIN1POLBNT5E
SCHEMBL16229229 0.88 MAPT (0.31) MAPTABL1RIN1
SCHEMBL30274756 0.88 ACHE (0.33) MAPTABL1RIN1POLBNT5E
SCHEMBL27056650 0.88 ACHE (0.33) MAPTABL1RIN1POLBNT5E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130123481-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF modeRNA Therapeutics (US) 2013-05-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130123481-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF ADAR, NT5C3B, NSUN2 MAPT 3587/4885ABL1 1325/4885RIN1 3879/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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