Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL14935731 | 0.98 | L3MBTL1 (0.47) | L3MBTL1KDM4EGLAALDH1A1IDO1 | |
| SCHEMBL18324623 | 0.81 | CA2 (0.45) | ALDH1A1IDO1HTTLMNA | |
| SCHEMBL20278237 | 0.81 | IDO1 (0.44) | L3MBTL1ALDH1A1IDO1KMT2AMEN1 | |
| SCHEMBL24574882 | 0.80 | KMT2A (0.45) | L3MBTL1KDM4EGLAIDO1KMT2A | |
| SCHEMBL1751119 | 0.79 | KMT2A (0.45) | KDM4EIDO1KMT2AMEN1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL15663073 | 0.79 | CA2 (0.43) | ALDH1A1IDO1KMT2AHTTLMNA | |
| SCHEMBL11197630 | 0.78 | ALDH1A1 (0.44) | L3MBTL1KDM4EALDH1A1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL6870271 | 0.78 | IDO1 (0.41) | ALDH1A1IDO1KMT2AMEN1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4737475 | 0.77 | ALDH1A1 (0.43) | L3MBTL1KDM4EALDH1A1IDO1KMT2A | |
| Hydrochloric Acid SCHEMBL6867291 | 0.76 | KMT2A (0.43) | KDM4EIDO1KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9433631-B2 | 4-pregenen-11β-17-21-triol-3,20-dione derivatives | ALLERGAN, INC. (US) | 2016-09-06 | — | — | US | disclosed |
| US-20150057258-A1 | 4-PREGENEN-11BETA-17-21-TRIOL-3,20-DIONE DERIVATIVES | ALLERGAN, INC. | 2015-02-26 | — | — | US | disclosed |
| US-8906892-B2 | 4-pregenen-11β-17-21-triol-3,20-dione derivatives | ALLERGAN, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| WO-2013071009-A1 | 4 - PREGENEN- 11SS - 17 - 21 -TRIOL-3, 20 -DIONE DERIVATIVES FOR THE TREATMENT OF OCULAR CONDITIONS | ALLERGAN, INC. (US) | 2013-05-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150057258-A1 | 4-PREGENEN-11BETA-17-21-TRIOL-3,20-DIONE DERIVATIVES | NR3C2, HSD3B1, HSD3B2 | L3MBTL1 4871/4885KDM4E 3046/4885GLA 3152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.