Sugi Predict

Sugi Predict / Compounds / SCHEMBL14949277

SCHEMBL14949277

SCHEMBL14949277

COc1cc(Oc2ccc(-c3nnc(Nc4cccc(C)c4)[nH]3)cc2)ncn1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDR P35968 3/20 0.43
▸ TNNI3K Q59H18 2/20 0.43
▸ MAPK14 Q16539 1/20 0.42
▸ EGFR P00533 6/20 0.39
▸ RAB9A P51151 3/20 0.38
▸ MAPT P10636 3/20 0.38
▸ SMN1; SMN2 Q16637 2/20 0.38
▸ MEN1 O00255 2/20 0.38
▸ NPC1 O15118 2/20 0.38
▸ KMT2A Q03164 2/20 0.38
▸ KDM4E B2RXH2 2/20 0.38
▸ ABL1 P00519 1/20 0.38
▸ ABL2 P42684 1/20 0.38
▸ ALDH1A1 P00352 1/20 0.38
▸ GAA P10253 1/20 0.38
▸ TTBK1 Q5TCY1 1/20 0.36
▸ TTBK2 Q6IQ55 1/20 0.36
▸ HTT P42858 2/20 0.35
▸ TSHR P16473 1/20 0.35
▸ MAPK1 P28482 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14949358 0.91 KDR (0.38) KDRTNNI3KMAPK14EGFRRAB9A
SCHEMBL14949257 0.90 KDR (0.42) KDRTNNI3KMAPK14EGFRRAB9A
SCHEMBL12336301 0.87 KDR (0.59) KDRTNNI3KMAPK14EGFR
SCHEMBL14949279 0.87 PDGFRB (0.37) KDREGFRRAB9AMAPTSMN1; SMN2
SCHEMBL14949198 0.87 KDR (0.39) KDRMAPTKMT2ATTBK1TTBK2
SCHEMBL14949271 0.84 PIK3CG (0.39) KDREGFRMAPTMEN1KMT2A
SCHEMBL14949183 0.84 PIK3CA (0.38) KDRTNNI3KMAPK14EGFRMAPT
SCHEMBL14949267 0.82 PIK3CA (0.38) KDRTNNI3KMAPK14RAB9AMAPT
SCHEMBL14949202 0.82 CSF1R (0.50) KDREGFR
SCHEMBL14949184 0.81 KMT2A (0.42) KDRMAPK14RAB9AMAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2016-04-07 — — US disclosed
US-9212151-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-12-15 — — US disclosed
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2015-06-11 — — US disclosed
US-8957216-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-02-17 — — US disclosed
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION AMITECH THERAPEUTIC SOLUTIONS INC (US) 2013-05-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION MAP4K2, MAP3K20, MAP3K19 KDR 533/4885TNNI3K 56/4885MAPK14 90/4885
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 KDR 533/4885TNNI3K 56/4885MAPK14 90/4885
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 KDR 533/4885TNNI3K 56/4885MAPK14 90/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.