Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.38 |
| ▸ | TNNI3K | Q59H18 | 3/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | CDK11B | P21127 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | CDKL2 | Q92772 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.33 |
| ▸ | MET | P08581 | 2/20 | 0.31 |
| ▸ | TEK | Q02763 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18016751 | 0.91 | PDGFRB (0.37) | KDRMAPK14TNNI3KPDGFRBKIT | |
| SCHEMBL14949247 | 0.88 | RAB9A (0.37) | KDRTNNI3KPDGFRBKITPDGFRA | |
| SCHEMBL12336276 | 0.87 | PDGFRB (0.49) | KDRMAPK14TNNI3KPDGFRBKIT | |
| SCHEMBL14949394 | 0.85 | RAB9A (0.41) | KDRMAPK14TNNI3KPDGFRBKIT | |
| SCHEMBL14949248 | 0.84 | SMN1; SMN2 (0.38) | RAB9ANPC1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL14949254 | 0.83 | RAB9A (0.38) | RAB9ANPC1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL14949246 | 0.81 | SMN1; SMN2 (0.38) | RAB9ANPC1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL14949265 | 0.80 | NUDT1 (0.38) | RAB9ANPC1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL14949331 | 0.80 | RAB9A (0.39) | RAB9ANPC1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL12336527 | 0.79 | PDGFRB (0.41) | KDRPDGFRBKITPDGFRACDK11B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130123284-A1 | HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION | AMITECH THERAPEUTIC SOLUTIONS INC (US) | 2013-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130123284-A1 | HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION | MAP4K2, MAP3K20, MAP3K19 | KDR 533/4885MAPK14 90/4885TNNI3K 56/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.