Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402785 | 0.89 | ALDH1A1 (0.56) | GAASMN1; SMN2ALDH1A1MAPK1LMNA | |
| SCHEMBL3401952 | 0.88 | GAA (0.55) | GAASMN1; SMN2ALDH1A1LMNATDP1 | |
| SCHEMBL14978998 | 0.83 | GAA (0.54) | GAASMN1; SMN2ALDH1A1MAPK1LMNA | |
| SCHEMBL8271230 | 0.82 | L3MBTL1 (0.45) | SMN1; SMN2LMNA | |
| SCHEMBL14009872 | 0.82 | ALDH1A1 (0.40) | GAASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL14949553 | 0.82 | GAA (0.50) | GAASMN1; SMN2ALDH1A1MAPK1LMNA | |
| SCHEMBL20002872 | 0.80 | GAA (0.44) | GAASMN1; SMN2ALDH1A1MAPK1LMNA | |
| SCHEMBL3938968 | 0.79 | GAA (0.48) | GAASMN1; SMN2ALDH1A1MAPK1LMNA | |
| SCHEMBL2503145 | 0.78 | GAA (0.47) | GAASMN1; SMN2ALDH1A1MAPK1LMNA | |
| SCHEMBL16405708 | 0.77 | SMN1; SMN2 (0.47) | GAASMN1; SMN2ALDH1A1LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | claimed |
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | disclosed |