Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14949540 | 0.80 | GAA (0.47) | GAASMN1; SMN2ALDH1A1MAPK1LMNA | |
| SCHEMBL14978998 | 0.79 | GAA (0.54) | GAASMN1; SMN2ALDH1A1MAPK1LMNA | |
| SCHEMBL3938968 | 0.75 | GAA (0.48) | GAASMN1; SMN2ALDH1A1MAPK1LMNA | |
| SCHEMBL14949553 | 0.75 | GAA (0.50) | GAASMN1; SMN2ALDH1A1MAPK1LMNA | |
| SCHEMBL2503145 | 0.74 | GAA (0.47) | GAASMN1; SMN2ALDH1A1MAPK1LMNA | |
| SCHEMBL2350150 | 0.72 | GAA (0.50) | GAASMN1; SMN2ALDH1A1MAPK1LMNA | |
| SCHEMBL4132459 | 0.71 | GNAI3 (0.61) | GAALMNATDP1POLB | |
| SCHEMBL3402785 | 0.70 | ALDH1A1 (0.56) | GAASMN1; SMN2ALDH1A1MAPK1LMNA | |
| SCHEMBL16671006 | 0.69 | GAA (0.43) | GAASMN1; SMN2ALDH1A1MAPK1LMNA | |
| SCHEMBL4723862 | 0.69 | SMN1; SMN2 (0.49) | GAASMN1; SMN2ALDH1A1MAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |