Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.40 |
| ▸ | TEK | Q02763 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 3/20 | 0.35 |
| ▸ | FLT1 | P17948 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12892600 | 0.84 | NPC1 (0.42) | KDRTEK | |
| SCHEMBL14949659 | 0.81 | KDR (0.58) | KDRBRAFFLT1ABL1AURKA | |
| SCHEMBL4310546 | 0.81 | KDR (0.41) | KDRTEKMAPK14CDK8PIK3CG | |
| SCHEMBL14949663 | 0.80 | MET (0.49) | KDRTEKFLT1 | |
| SCHEMBL4684136 | 0.76 | PARP10 (0.44) | MAPK14BRAF | |
| SCHEMBL3561767 | 0.76 | MAPK14 (0.61) | KDRMAPK14MAPK13BRAFFLT1 | |
| SCHEMBL14949682 | 0.76 | CDK8 (0.58) | MAPK14CDK8 | |
| SCHEMBL3672879 | 0.75 | KDR (0.62) | KDRTEKBRAFFLT1ABL1 | |
| SCHEMBL1259022 | 0.74 | MAPK14 (0.34) | KDRTEKMAPK14PIK3CG | |
| SCHEMBL4286488 | 0.72 | KDR (0.51) | KDRTEKBRAFFLT1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445509-B2 | Fused heterocyclic derivatives and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-05-21 | — | — | US | disclosed |