Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 14/20 | 0.49 |
| ▸ | KDR | P35968 | 5/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | PNLIP | P16233 | 1/20 | 0.40 |
| ▸ | PARG | Q86W56 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | TEK | Q02763 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12892593 | 0.85 | MET (0.46) | METKDRFLT1FLT4PNLIP | |
| SCHEMBL4310546 | 0.84 | KDR (0.41) | KDRTEK | |
| SCHEMBL14949679 | 0.82 | KDR (0.70) | METKDRFLT1FLT4 | |
| SCHEMBL14949674 | 0.80 | KDR (0.40) | KDRFLT1TEK | |
| SCHEMBL2260442 | 0.80 | MET (0.55) | METKDRPNLIPPARGAXL | |
| SCHEMBL5151671 | 0.77 | PNLIP (0.52) | METKDRPNLIPPARGFFAR1 | |
| SCHEMBL14949681 | 0.77 | CDK8 (0.55) | MET | |
| SCHEMBL4447930 | 0.76 | KDR (0.70) | METKDRFLT1FLT4 | |
| SCHEMBL1260140 | 0.75 | MET (0.38) | METKDRFLT1FLT4 | |
| SCHEMBL1137330 | 0.75 | MET (0.73) | METKDRAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445509-B2 | Fused heterocyclic derivatives and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-05-21 | — | — | US | disclosed |