Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL328387 | 0.83 | MAPK14 (0.54) | MAPTL3MBTL1NPSR1KDM4EPOLB | |
| SCHEMBL779089 | 0.82 | ACHE (0.53) | MAPTL3MBTL1NPSR1KDM4EPOLB | |
| SCHEMBL15596867 | 0.81 | MAP2K1 (0.48) | L3MBTL1NPSR1LMNATSHR | |
| SCHEMBL15596859 | 0.80 | SMN1; SMN2 (0.46) | MAPTL3MBTL1NPSR1KDM4EPOLB | |
| SCHEMBL11990101 | 0.78 | MAOB (0.48) | MAPTL3MBTL1NPSR1KDM4EPOLB | |
| SCHEMBL11989286 | 0.78 | MAPT (0.56) | MAPTL3MBTL1NPSR1KDM4EPOLB | |
| SCHEMBL14471077 | 0.78 | L3MBTL1 (0.46) | MAPTL3MBTL1NPSR1KDM4EPOLB | |
| SCHEMBL4016806 | 0.77 | TTR (0.56) | MAPTL3MBTL1NPSR1KDM4EPOLB | |
| SCHEMBL425685 | 0.77 | RAB9A (0.50) | SMN1; SMN2LMNAACHEBCHEMEN1 | |
| SCHEMBL27956884 | 0.76 | FFAR1 (0.47) | MAPTL3MBTL1NPSR1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014028334-A1 | SELECTIVE MMP INHIBITORS | SYMPHONY EVOLUTION, INC. (US) | 2014-02-20 | — | — | WO | disclosed |
| EP-1511488-B1 | HUMAN ADAM-10 INHIBITORS | SYMPHONY EVOLUTION INC (US) | 2013-05-22 | — | — | EP | disclosed |