Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.54 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL779089 | 0.85 | ACHE (0.53) | MAPK14KDM4EMAPTL3MBTL1POLB | |
| SCHEMBL9339651 | 0.84 | HSPB1 (0.58) | MAPK14TRPA1L3MBTL1POLBNFE2L2 | |
| SCHEMBL31120710 | 0.83 | L3MBTL1 (0.67) | KDM4EMAPTL3MBTL1POLBNPSR1 | |
| SCHEMBL14959583 | 0.83 | MAPT (0.48) | MAPK14KDM4EMAPTL3MBTL1POLB | |
| SCHEMBL27115312 | 0.83 | ALDH1A1 (0.56) | MAPK14TRPA1L3MBTL1HSPB1LMNA | |
| SCHEMBL11989286 | 0.81 | MAPT (0.56) | MAPK14KDM4EMAPTL3MBTL1POLB | |
| SCHEMBL14471077 | 0.81 | L3MBTL1 (0.46) | MAPK14TRPA1KDM4EMAPTL3MBTL1 | |
| SCHEMBL11990101 | 0.81 | MAOB (0.48) | KDM4EMAPTL3MBTL1POLBNPSR1 | |
| SCHEMBL28014098 | 0.80 | TRPA1 (0.52) | MAPK14TRPA1L3MBTL1NFE2L2SMN1; SMN2 | |
| SCHEMBL4016806 | 0.80 | TTR (0.56) | KDM4EMAPTL3MBTL1POLBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428509-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |