Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KCNMA1 | Q12791 | 4/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27789807 | 0.87 | KCNMA1 (0.47) | KCNMA1MEN1KMT2AAKR1C3AKR1C2 | |
| SCHEMBL1495893 | 0.85 | THRB (0.45) | L3MBTL1KCNMA1MEN1KMT2APOLB | |
| SCHEMBL27768216 | 0.83 | AKR1C3 (0.52) | L3MBTL1MEN1KMT2AAKR1C3AKR1C2 | |
| SCHEMBL21378883 | 0.82 | L3MBTL1 (0.50) | L3MBTL1KCNMA1APPMEN1KMT2A | |
| SCHEMBL29822637 | 0.82 | L3MBTL1 (0.50) | L3MBTL1KCNMA1APPMEN1KMT2A | |
| SCHEMBL29532900 | 0.74 | AKR1C3 (0.67) | L3MBTL1KCNMA1APPMEN1KMT2A | |
| SCHEMBL2112961 | 0.74 | AKR1C3 (0.67) | L3MBTL1KCNMA1APPMEN1KMT2A | |
| SCHEMBL1495954 | 0.74 | KMT2A (0.46) | KCNMA1KMT2APOLBCYP1A2HPGD | |
| SCHEMBL1495953 | 0.74 | KMT2A (0.46) | KCNMA1KMT2APOLBCYP1A2HPGD | |
| SCHEMBL27789698 | 0.74 | MEN1 (0.41) | L3MBTL1MEN1KMT2AAKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781661-B1 | VASOPRESSIN V1A ANTAGONISTS | VANTIA LTD (GB) | 2017-06-07 | — | — | EP | disclosed |
| EP-2256119-B1 | Vasopressin V1a antagonists | VANTIA LTD (GB) | 2012-05-09 | — | — | EP | disclosed |
| EP-2292621-A1 | Vasopressin v1a antagonists | Vantia Limited (GB) | 2011-03-09 | — | — | EP | disclosed |
| EP-2264037-A1 | Vasopressin v1a antagonists | Vantia Limited (GB) | 2010-12-22 | — | — | EP | disclosed |
| EP-2256119-A1 | Vasopressin V1a antagonists | Vantia Limited (GB) | 2010-12-01 | — | — | EP | disclosed |