Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.33 |
| ▸ | MAPT | P10636 | 6/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | XBP1 | P17861 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7759160 | 0.78 | KDM1A (0.38) | POLBALDH1A1MAPTKMT2ARAB9A | |
| SCHEMBL2945266 | 0.78 | PDE4A (0.41) | POLBALDH1A1MAPTKMT2ARAB9A | |
| SCHEMBL2945263 | 0.78 | PDE4A (0.41) | POLBALDH1A1MAPTKMT2ARAB9A | |
| SCHEMBL24098444 | 0.75 | ALDH1A1 (0.33) | POLBALDH1A1MAPTKMT2ARAB9A | |
| SCHEMBL10445301 | 0.72 | KMT2A (0.35) | ALDH1A1MAPTKMT2ARAB9AMAPK1 | |
| SCHEMBL15290752 | 0.69 | MAOA (0.33) | ALDH1A1MAPTKMT2AMAPK1MEN1 | |
| SCHEMBL27489283 | 0.69 | ALDH1A1 (0.39) | POLBALDH1A1MAPTKMT2ARAB9A | |
| SCHEMBL28174232 | 0.67 | TDP1 (0.50) | POLBALDH1A1MAPTKMT2ARAB9A | |
| SCHEMBL9614957 | 0.66 | CES2 (0.44) | ALDH1A1MAPTKMT2AMAPK1MEN1 | |
| SCHEMBL892193 | 0.66 | CES2 (0.44) | ALDH1A1MAPTKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445509-B2 | Fused heterocyclic derivatives and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-05-21 | — | — | US | disclosed |