Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | HPGD | P15428 | 1/20 | 0.71 |
| ▸ | NPC1 | O15118 | 6/20 | 0.69 |
| ▸ | RAB9A | P51151 | 6/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2556482 | 0.83 | ALDH1A1 (0.69) | MAPTLMNANPC1RAB9AKDM4E | |
| SCHEMBL25436481 | 0.82 | ALDH1A1 (0.65) | MAPTL3MBTL1LMNAHPGDNPC1 | |
| SCHEMBL4293558 | 0.82 | ALDH1A1 (0.80) | MAPTL3MBTL1LMNAHPGDNPC1 | |
| SCHEMBL4912964 | 0.82 | NPC1 (0.80) | MAPTL3MBTL1LMNAHPGDNPC1 | |
| SCHEMBL12555378 | 0.80 | NPC1 (0.64) | MAPTL3MBTL1LMNAHPGDNPC1 | |
| SCHEMBL12218454 | 0.79 | ALDH1A1 (0.55) | MAPTL3MBTL1LMNAHPGDNPC1 | |
| SCHEMBL11691133 | 0.79 | MAPT (0.58) | MAPTL3MBTL1LMNAHPGDNPC1 | |
| SCHEMBL16655883 | 0.79 | NPC1 (0.74) | MAPTL3MBTL1LMNAHPGDNPC1 | |
| SCHEMBL7662976 | 0.78 | NPC1 (0.62) | MAPTL3MBTL1LMNAHPGDNPC1 | |
| SCHEMBL21436507 | 0.78 | RAB9A (0.66) | MAPTL3MBTL1LMNAHPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445517-B2 | Stat modulators | DANA-FARBER CANCER INSTITUTE (US) | 2013-05-21 | — | — | US | disclosed |