Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.74 |
| ▸ | RAB9A | P51151 | 5/20 | 0.74 |
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.53 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4293558 | 0.88 | ALDH1A1 (0.80) | NPC1RAB9ATSHRMAPK10ALDH1A1 | |
| SCHEMBL4912964 | 0.85 | NPC1 (0.80) | NPC1RAB9ATSHRMAPK10ALDH1A1 | |
| SCHEMBL6720448 | 0.81 | NPC1 (0.73) | NPC1RAB9ATSHRMAPK10ALDH1A1 | |
| SCHEMBL14960451 | 0.79 | MAPT (0.71) | NPC1RAB9ATSHRALDH1A1L3MBTL1 | |
| SCHEMBL4908172 | 0.77 | ALDH1A1 (0.84) | NPC1RAB9ATSHRMAPK10ALDH1A1 | |
| SCHEMBL5696432 | 0.75 | ALDH1A1 (0.80) | NPC1RAB9ATSHRMAPK10ALDH1A1 | |
| SCHEMBL12555378 | 0.75 | NPC1 (0.64) | NPC1RAB9ATSHRALDH1A1L3MBTL1 | |
| SCHEMBL5696463 | 0.75 | ALDH1A1 (0.85) | NPC1RAB9ATSHRMAPK10ALDH1A1 | |
| SCHEMBL6032429 | 0.75 | HCAR2 (0.81) | NPC1RAB9ATSHRMAPK10ALDH1A1 | |
| SCHEMBL4915695 | 0.75 | HCAR2 (0.76) | NPC1RAB9ATSHRMAPK10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083561-A1 | HETEROARYL LINKED QUINOLINYL MODULATORS OF RORYT | Janssen Pharmaceutica N.V. (BE) | 2016-10-26 | — | — | EP | disclosed |
| WO-2015057200-A1 | HETEROARYL LINKED QUINOLINYL MODULATORS OF RORϒT | JANSSEN PHARMACEUTICA NV (BE) | 2015-04-23 | — | — | WO | disclosed |