Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.58 |
| ▸ | HTR3B | O95264 | 1/20 | 0.58 |
| ▸ | HTR3A | P46098 | 1/20 | 0.58 |
| ▸ | BACE1 | P56817 | 1/20 | 0.58 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.58 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3716080 | 0.89 | MAP4K4 (0.49) | HTR3EHTR3BHTR3ABACE1HTR3D | |
| Bromide SCHEMBL2380345 | 0.87 | MAP4K4 (0.48) | HTR3EHTR3BHTR3ABACE1HTR3D | |
| Bromide SCHEMBL118833 | 0.87 | MAP4K4 (0.48) | HTR3EHTR3BHTR3ABACE1HTR3D | |
| SCHEMBL14964175 | 0.80 | CHEK2 (0.45) | MAP4K4MEN1KMT2APGRTHRB | |
| SCHEMBL11713250 | 0.75 | HTR3E (0.58) | HTR3EHTR3BHTR3ABACE1HTR3D | |
| SCHEMBL31651401 | 0.74 | PLAU (0.61) | HTR3EHTR3BHTR3ABACE1HTR3D | |
| SCHEMBL1887281 | 0.74 | PLAU (0.61) | HTR3EHTR3BHTR3ABACE1HTR3D | |
| SCHEMBL658809 | 0.74 | HTR3E (1.00) | HTR3EHTR3BHTR3ABACE1HTR3D | |
| SCHEMBL11712219 | 0.73 | ALDH1A1 (0.58) | HTR3EHTR3BHTR3ABACE1HTR3D | |
| SCHEMBL3866103 | 0.72 | HTR3E (0.55) | HTR3EHTR3BHTR3ABACE1HTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450354-B2 | Substituted imidazo[1,2-b]pyridazine derivatives, pharmaceutical compositions, and methods of use as β-secretase inhibitors | HIGH POINT PHARMACEUTICALS, LLC (US) | 2013-05-28 | — | — | US | claimed |