Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.55 |
| ▸ | HTR3B | O95264 | 1/20 | 0.55 |
| ▸ | HTR3A | P46098 | 1/20 | 0.55 |
| ▸ | BACE1 | P56817 | 1/20 | 0.55 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.55 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.55 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | MTOR | P42345 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 8/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3830569 | 0.88 | HTR3E (0.44) | HTR3EHTR3BHTR3ABACE1HTR3D | |
| SCHEMBL10051515 | 0.73 | MEN1 (0.60) | ALDH1A1TDP1MEN1KMT2AMAPT | |
| SCHEMBL11713250 | 0.73 | HTR3E (0.58) | HTR3EHTR3BHTR3ABACE1HTR3D | |
| SCHEMBL14964176 | 0.72 | HTR3E (0.58) | HTR3EHTR3BHTR3ABACE1HTR3D | |
| SCHEMBL658809 | 0.72 | HTR3E (1.00) | HTR3EHTR3BHTR3ABACE1HTR3D | |
| SCHEMBL11712219 | 0.71 | ALDH1A1 (0.58) | HTR3EHTR3BHTR3ABACE1HTR3D | |
| SCHEMBL989969 | 0.69 | ASIC3 (0.51) | HTR3EHTR3BHTR3ABACE1HTR3D | |
| SCHEMBL1887281 | 0.69 | PLAU (0.61) | HTR3EHTR3BHTR3ABACE1HTR3D | |
| SCHEMBL31651401 | 0.69 | PLAU (0.61) | HTR3EHTR3BHTR3ABACE1HTR3D | |
| SCHEMBL725354 | 0.68 | PLAU (0.66) | HTR3EHTR3BHTR3ABACE1HTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713793-A4 | PYRIMIDINONE COMPOUNDS USEFUL AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2009-09-02 | — | — | EP | disclosed |
| US-20070117818-A1 | Pyrimidinone compounds useful as kinase inhibitors | HASEGAWA MASAICHI | 2007-05-24 | — | — | US | disclosed |
| US-20070117818-A1 | Pyrimidinone compounds useful as kinase inhibitors | HASEGAWA MASAICHI | 2007-05-24 | — | — | US | disclosed |
| EP-1713793-A2 | PYRIMIDINONE COMPOUNDS USEFUL AS KINASE INHIBITORS | Smithkline Beecham Corporation (US) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005076854-A2 | PYRIMIDINONE COMPOUNDS USEFUL AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070117818-A1 | Pyrimidinone compounds useful as kinase inhibitors | HIPK3, HIPK1, HIPK2 | HTR3E 1887/4885HTR3B 2269/4885HTR3A 2217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.