Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.35 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 7/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14964242 | 0.88 | ALDH1A1 (0.32) | GAAALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL15100371 | 0.85 | LMNA (0.41) | GAAALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL4971385 | 0.82 | ALDH1A1 (0.38) | GAAALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL14964354 | 0.82 | ALDH1A1 (0.39) | GAAALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL14964311 | 0.81 | PROKR1 (0.37) | GAALMNAKMT2AMEN1 | |
| SCHEMBL5630196 | 0.81 | LMNA (0.40) | GAAALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL5630189 | 0.81 | LMNA (0.40) | GAAALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL14964369 | 0.81 | ALDH1A1 (0.36) | GAAALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL14964244 | 0.80 | ALDH1A1 (0.36) | GAAALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL14964280 | 0.80 | MAPT (0.46) | GAAALDH1A1LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450351-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2013-05-28 | — | — | US | claimed |