Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | UBE2M | P61081 | 2/20 | 0.33 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | CLPP | Q16740 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.30 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14964261 | 0.88 | CYP2A13 (0.37) | ALDH1A1LMNAKMT2A | |
| SCHEMBL4981542 | 0.86 | SOS1 (0.37) | KDM4EALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL16581752 | 0.83 | ACHE (0.45) | TP53UBE2MDCUN1D1KMT2A | |
| SCHEMBL15100448 | 0.82 | POLB (0.43) | TP53UBE2MDCUN1D1POLBALDH1A1 | |
| SCHEMBL14964196 | 0.82 | IDO1 (0.32) | ALDH1A1 | |
| SCHEMBL5631166 | 0.81 | LMNA (0.40) | TP53KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL14964179 | 0.80 | HPGD (0.36) | MCHR1MAPTKMT2AKCNH2 | |
| SCHEMBL14964338 | 0.80 | IDO1 (0.35) | ALDH1A1KMT2A | |
| SCHEMBL14964328 | 0.79 | IDO1 (0.37) | ALDH1A1 | |
| SCHEMBL15093288 | 0.78 | KMT2A (0.30) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450351-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2013-05-28 | — | — | US | claimed |