Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MAOB | P27338 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NNMT | P40261 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38086 | 0.72 | LMNA (0.38) | LMNAMAOBKDM4ENPC1RAB9A | |
| SCHEMBL1457173 | 0.72 | KDM4E (0.69) | LMNAKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL1456221 | 0.71 | NNMT (0.46) | LMNAMAOBKDM4ENPC1RAB9A | |
| SCHEMBL1967426 | 0.69 | CLK4 (0.56) | KDM4ENPC1RAB9AALDH1A1PKM | |
| SCHEMBL1450475 | 0.69 | KDM4E (0.54) | LMNAKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL751581 | 0.69 | HDAC8 (0.33) | LMNAKDM4E | |
| SCHEMBL1967614 | 0.68 | ALDH1A1 (0.43) | LMNAKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL18228114 | 0.67 | — | — | |
| SCHEMBL3827760 | 0.67 | — | — | |
| SCHEMBL16048094 | 0.67 | TRIM24 (0.41) | LMNAMAOBNPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780332-A1 | MORPHOLINYL BENZOTRIAZINE FOR USE IN CANCER THERAPY | Merck Patent GmbH (DE) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013072015-A1 | MORPHOLINYL BENZOTRIAZINE FOR USE IN CANCER THERAPY | MERCK PATENT GMBH (DE) | 2013-05-23 | — | — | WO | disclosed |