⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14965680 | 0.90 | ADRB2 (0.52) | — | |
| SCHEMBL16293296 | 0.89 | POLB (0.62) | — | |
| SCHEMBL14965005 | 0.85 | LMNA (0.64) | — | |
| SCHEMBL16293589 | 0.83 | LMNA (0.58) | — | |
| SCHEMBL14965036 | 0.82 | LMNA (0.67) | — | |
| SCHEMBL16293493 | 0.82 | ADRB3 (0.64) | — | |
| SCHEMBL14965149 | 0.81 | — | — | |
| SCHEMBL16292948 | 0.81 | LMNA (0.56) | — | |
| SCHEMBL17599008 | 0.81 | KMT2A (0.77) | — | |
| SCHEMBL14965614 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780343-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | Xention Limited (GB) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013072694-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | XENTION LIMITED (GB) | 2013-05-23 | — | — | WO | disclosed |