Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KCNA1 | Q09470 | 5/20 | 0.42 |
| ▸ | KCNAB1 | Q14722 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.37 |
| ▸ | STS | P08842 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14965880 | 0.91 | P2RY12 (0.38) | LMNAPOLBKCNA1KCNAB1KDM4E | |
| SCHEMBL14966229 | 0.90 | KDM4E (0.41) | LMNAKDM4EKMT2ASMN1; SMN2P2RY12 | |
| SCHEMBL14965726 | 0.85 | NPC1 (0.45) | LMNAPOLBKDM4EALDH1A1TSHR | |
| SCHEMBL14966258 | 0.79 | KMT2A (0.46) | LMNAPOLBKDM4EALDH1A1HSD17B10 | |
| SCHEMBL14966280 | 0.75 | SMN1; SMN2 (0.52) | LMNAPOLBALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL14965955 | 0.75 | MAPK1 (0.44) | LMNAKDM4EALDH1A1SMN1; SMN2GAA | |
| SCHEMBL14966116 | 0.75 | MAPT (0.46) | LMNAKDM4EALDH1A1TSHRKMT2A | |
| SCHEMBL14965945 | 0.75 | BLM (0.55) | LMNAALDH1A1TSHRKMT2ASMN1; SMN2 | |
| SCHEMBL14966075 | 0.74 | KDM4E (0.46) | LMNAKDM4EALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL14965906 | 0.73 | PANK3 (0.42) | LMNASMN1; SMN2P2RY12GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | claimed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |