Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | PKM | P14618 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14965648 | 0.90 | PKM (0.45) | KMT2APKMMEN1ALDH1A1POLB | |
| SCHEMBL14966069 | 0.89 | PKM (0.46) | KMT2APKMMEN1ALDH1A1HTT | |
| SCHEMBL14966078 | 0.88 | PKM (0.52) | KMT2APKMMEN1ALDH1A1HTT | |
| SCHEMBL14966236 | 0.86 | PKM (0.49) | KMT2APKMALDH1A1HTTHSD11B1 | |
| SCHEMBL14966092 | 0.83 | LMNA (0.42) | PKMPOLBLMNATSHR | |
| SCHEMBL14965486 | 0.79 | LMNA (0.42) | KMT2AALDH1A1POLBGAASMN1; SMN2 | |
| SCHEMBL14965372 | 0.78 | KCNH2 (0.38) | PKMALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL14965726 | 0.74 | NPC1 (0.45) | KMT2AMEN1ALDH1A1HTTPOLB | |
| SCHEMBL3469461 | 0.72 | CHRM1 (0.39) | KMT2APKMALDH1A1POLBLMNA | |
| SCHEMBL25406378 | 0.70 | POLB (0.71) | KMT2APKMMEN1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | claimed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |