Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | PKLR | P30613 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966069 | 0.90 | PKM (0.46) | PKMPKLRKMT2AMEN1POLB | |
| SCHEMBL14966258 | 0.90 | KMT2A (0.46) | PKMKMT2AMEN1POLBGAA | |
| SCHEMBL14966236 | 0.87 | PKM (0.49) | PKMPKLRKMT2AGAAL3MBTL1 | |
| SCHEMBL14966078 | 0.87 | PKM (0.52) | PKMPKLRKMT2AMEN1POLB | |
| SCHEMBL14965846 | 0.82 | HTT (0.39) | KMT2APOLBGAALMNAMAPK1 | |
| SCHEMBL14966092 | 0.79 | LMNA (0.42) | PKMPOLBTSHRLMNA | |
| SCHEMBL1046316 | 0.78 | CHRM1 (0.40) | PKMKMT2APOLBLMNAALDH1A1 | |
| SCHEMBL14965880 | 0.78 | P2RY12 (0.38) | PKMKMT2APOLBHSD17B10LMNA | |
| SCHEMBL5536974 | 0.77 | ALDH1A1 (0.52) | KMT2AMEN1POLBHSD17B10TSHR | |
| SCHEMBL14965372 | 0.76 | KCNH2 (0.38) | PKMLMNAL3MBTL1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | claimed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |