Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14965530 | 1.00 | RAB9A (0.37) | RAB9ANPC1TP53MAPK1PLAU | |
| SCHEMBL14965603 | 0.85 | POLB (0.33) | RAB9ANPC1POLB | |
| SCHEMBL364193 | 0.81 | NPC1 (0.34) | RAB9ANPC1TP53MAPK1TRPV1 | |
| SCHEMBL363549 | 0.81 | NPC1 (0.34) | RAB9ANPC1TP53MAPK1TRPV1 | |
| SCHEMBL363211 | 0.81 | NPC1 (0.34) | RAB9ANPC1TP53MAPK1TRPV1 | |
| SCHEMBL363771 | 0.81 | NPC1 (0.42) | RAB9ANPC1LMNAMAPTMEN1 | |
| SCHEMBL363964 | 0.80 | GPR183 (0.38) | RAB9ANPC1TP53MAPK1LMNA | |
| SCHEMBL14894794 | 0.80 | GPR183 (0.38) | RAB9ANPC1TP53MAPK1LMNA | |
| SCHEMBL364183 | 0.78 | GPR183 (0.34) | RAB9ANPC1TP53MAPK1TRPV1 | |
| SCHEMBL364659 | 0.78 | KCNK3 (0.33) | RAB9ANPC1TRPV1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780330-A1 | 1-PYRIDAZINYL-HYDROXYIMINO- 3- PHENYL- PROPANES AS GPBAR1 AGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013072265-A1 | 1-PYRIDAZINYL-HYDROXYIMINO- 3- PHENYL- PROPANES AS GPBAR1 AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-05-23 | — | — | WO | disclosed |