Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14894794 | 0.87 | GPR183 (0.38) | GPR183KCNH2NPC1RAB9AMEN1 | |
| SCHEMBL363964 | 0.87 | GPR183 (0.38) | GPR183KCNH2NPC1RAB9AMEN1 | |
| SCHEMBL364659 | 0.81 | KCNK3 (0.33) | NPC1RAB9AHSP90AA1ALDH1A1LMNA | |
| SCHEMBL363771 | 0.79 | NPC1 (0.42) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL14965530 | 0.78 | RAB9A (0.37) | NPC1RAB9AMEN1KMT2ATP53 | |
| SCHEMBL14965778 | 0.78 | RAB9A (0.37) | NPC1RAB9AMEN1KMT2ATP53 | |
| SCHEMBL14965127 | 0.78 | KMT2A (0.38) | NPC1RAB9AMEN1KMT2AHSP90AA1 | |
| SCHEMBL363549 | 0.77 | NPC1 (0.34) | NPC1RAB9ATP53MAPK1ALDH1A1 | |
| SCHEMBL364193 | 0.77 | NPC1 (0.34) | NPC1RAB9ATP53MAPK1ALDH1A1 | |
| SCHEMBL363211 | 0.77 | NPC1 (0.34) | NPC1RAB9ATP53MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |