Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 4/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL362592 | 0.83 | KCNN4 (0.37) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL14965530 | 0.81 | RAB9A (0.37) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL14965778 | 0.81 | RAB9A (0.37) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL13927990 | 0.81 | CES2 (0.37) | NPC1RAB9AL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL16222433 | 0.81 | KCNN4 (0.46) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL363549 | 0.80 | NPC1 (0.34) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL364193 | 0.80 | NPC1 (0.34) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL363211 | 0.80 | NPC1 (0.34) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL364183 | 0.79 | GPR183 (0.34) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL362081 | 0.79 | HSD17B1 (0.33) | ALDH1A1ESR1ESR2CYP3A4MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |