Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 3/20 | 0.40 |
| ▸ | CNR2 | P34972 | 3/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14965650 | 0.97 | CNR1 (0.42) | FGFR1FGFR2FGFR3CNR1CNR2 | |
| SCHEMBL14966145 | 0.91 | FGFR1 (0.43) | FGFR1FGFR2FGFR3CCR3DRD4 | |
| SCHEMBL14965563 | 0.91 | MCHR1 (0.42) | FGFR1FGFR2FGFR3CNR1CNR2 | |
| SCHEMBL14965814 | 0.89 | FGFR1 (0.41) | FGFR1FGFR2FGFR3CNR1CNR2 | |
| SCHEMBL14966019 | 0.88 | MCHR1 (0.39) | MCHR1 | |
| SCHEMBL14966188 | 0.88 | KDM4E (0.50) | FGFR1FGFR2FGFR3CCR3DRD4 | |
| SCHEMBL14965848 | 0.88 | MCHR1 (0.37) | MCHR1 | |
| SCHEMBL14966086 | 0.88 | FGFR1 (0.38) | FGFR1FGFR2FGFR3CNR1CNR2 | |
| SCHEMBL14965672 | 0.87 | DRD4 (0.47) | CCR3DRD4MCHR1KDM4E | |
| SCHEMBL14965509 | 0.85 | FGFR1 (0.42) | FGFR1FGFR2FGFR3CCR3MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | claimed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |