Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | CHKA | P35790 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MELK | Q14680 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966081 | 0.92 | KCNJ1 (0.39) | ALDH1A1POLBLMNAHTTSMN1; SMN2 | |
| SCHEMBL14966238 | 0.91 | MET (0.41) | METHRH3LMNAHTTSMN1; SMN2 | |
| SCHEMBL14965806 | 0.90 | MET (0.39) | METLMNAHTTSMN1; SMN2JAK2 | |
| SCHEMBL14965690 | 0.88 | HRH3 (0.54) | CHKAHRH3ALDH1A1POLBHTT | |
| SCHEMBL14966153 | 0.88 | JAK2 (0.38) | METALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL14965684 | 0.87 | CHKA (0.45) | CHKAHRH3ALDH1A1LMNAHTT | |
| SCHEMBL14965662 | 0.87 | ALDH1A1 (0.38) | ALDH1A1POLBLMNAHTTSMN1; SMN2 | |
| SCHEMBL14966035 | 0.87 | MCHR1 (0.42) | METALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL14966144 | 0.85 | JAK2 (0.38) | METHRH3LMNAHTTSMN1; SMN2 | |
| SCHEMBL14965840 | 0.85 | HRH3 (0.57) | CHKAHRH3ALDH1A1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | claimed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |